Workshop on Adverse Outcome Pathways (AOP) for radiation effects will be held virtually from 12 to 16 April 2021

The workshop is organized by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and with the contribution of OECD/ NEA/CRPPR/HLG-LDR, EURADOS and Health Canada.

Workshop objective statement

The concept of AOP is a new concept for radioprotection research that has originally been proposed and developed for the assessment of the toxicity of chemical stressors with an overall goal to aid regulation based off mechanistic knowledge of biological effects. Promoted and coordinated by the OECD, the AOP concept has been considered of value to radioprotection research that can help reconcile knowledge within radiation biology and epidemiology. The workshop’s main objective is to enhance awareness of and trigger interest in the AOP concept among those involved in radioprotection research. We therefore plan an in-depth immersion in the topic starting from the introduction to detailed coverage of the concept and to hands-on sessions during which specific AOPs will be proposed.

Program at a Glance

Session 1: Refresher Session: principles of AOPs arranged by the OECD AOP group – Monday 12 April (13h00-17h30)

Session 2: Use of AOP for risk assessment and risk management – Tuesday 13 April (14h00-16h00)

Session 3: Existing radiation AOPs and what AOPs need to be developed next – Tuesday 13 April (16h15-18h00)

Session 4: AOPs for chemicals and IR: what are the similarities and differences – Wednesday 14 April (14h30-16h15)

Session 5: Usefulness of AOP to identify knowledge gaps and define research priorities – Wednesday 14 April (16h30-18h00)

Session 6: Systems Biology approach as a tool for developing AOPs – Thursday 15 April (14h30-17h30)

More information about the workshop including the program and registration can be found at

You will be able to register to the different parts of the program and to attend the workshop using the online platform at the link above.

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